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Lipid-lowering benefits on clinical outcomes relative to baseline LDL value

KEY POINT

A meta-analysis published in JAMA of 34 trials involving more than 270,000 patients showed that more intensive LDL-lowering therapy compared with less-intensive therapy resulted in a greater reduction in the risk of all-cause and cardiovascular (CV) mortality, but only in patients with baseline LDL levels of 100 mg/dL or more.