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Safety concerns with digoxin use

KEY POINT

Use of digoxin in patients with atrial fibrillation (AF) was associated with an increased risk of death, specifically when serum concentrations were 1.2 ng/mL or higher or when treatment was newly initiated, according to results of a new analysis published in the Journal of the American College of Cardiology.

SOURCES

Lopes RD, et al. Digoxin and mortality in patients with atrial fibrillation. J Am Coll Cardiol. 2018;71(10):1063–74.        

Turakhia MP, et al. Digoxin in atrial fibrillation: Leave it out of the medicine cabinet. J Am Coll Cardiol. 2018;71(10):1075–7.