Medication Monitor



Generic Name (Trade Name—Company)
Notes
October 21, 2011

Linezolid

(Zyvox—Pfizer)
Update on interactions with serotonergic psych meds

Additional information regarding the interaction between linezolid and serotonergic psychiatric medications has been released by FDA. Most cases of serotonin syndrome with linezolid in the Adverse Event Reporting System (AERS) occurred in patients taking selective serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors, FDA said.

The risk with other psychiatric drugs with lesser degrees of serotonergic activity is not clear. The safety update lists serotonergic psychiatric drugs implicated in the AERS cases of serotonin syndrome with linezolid and other psychiatric drugs with varying degrees of serotonergic activity for which the risk of serotonin syndrome with linezolid is unclear.