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Botanicals Containing Aristolochia Causing Nephropathy, Cancer

KEY POINT

Botanical products containing the plant Aristolochia damage patients’ renal and urinary systems, causing end-stage nephropathy and urothelial carcinoma. This can lead to a need for prophylactic removal of the kidneys and ureters and renal transplantation. Some products are labeled as containing this ingredient. But in other cases, Aristolochia fangchi is present because it has been inadvertently substituted for Stephania tetrandra, which has a similar Chinese name.

SOURCES

www.cfsan.fda.gov/~dms/ds-bot.html.