Cardiology

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Aliskiren: Oral direct renin inhibitor for hypertension

KEY POINT

Aliskiren (Tekturna—Novartis) is the first available oral direct renin inhibitor. It is effective in significantly reducing blood pressure (BP) alone or in combination with other antihypertensive medications, with few associated adverse effects and reasonable interdosing BP variability. Aliskiren should not be used during the second and third trimesters of pregnancy because of risk to the fetus.