Drug Interactions Corner

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Increased risk of levofloxacin-associated hypoglycemia with polytherapy

KEY POINT

Fluoroquinolone-associated hypoglycemia continues to occur despite increased awareness about this potential adverse effect. Multiple drug interactions contributed to severe hypoglycemia in two recent case reports of older patients with type 2 diabetes who received levofloxacin with glyburide, low-molecular weight heparin, and opioids.