Drug Interactions Corner

Back to articles

PPI–clopidogrel interaction a concern after stent placement

November 10, 2015
  • Advising on this article:
  • Daniel S. Streetman

KEY POINT

Concomitant use of proton pump inhibitors (PPIs) and clopidogrel in patients with diabetes who received a drug-eluting stent was associated with an increased risk of acute coronary syndrome (ACS) compared with use of clopidogrel alone, according to results of a large nationwide cohort study.

SOURCES

Hsieh CF et al. Effects of clopidogrel and proton pump inhibitors on cardiovascular events in patients with type 2 diabetes mellitus after drug-eluting stent implantation: a nationwide cohort study. PLoS One. 2015;[Epub ahead of print]. 

Recent Articles

2215 Constitution Avenue NW, Washington, DC 20037 Telephone 202-628-4410 Fax 202-783-2351

© 2013 American Pharmacists Association All Rights Reserved.

About the American
Pharmacists Association

The American Pharmacists Association (APhA) is the organization whose members are recognized in society as essential in all patient care settings for optimal medication use that improves health, wellness and quality of life. Through information, education and advocacy, APhA empowers its members to improve medication use and advance patient care.

More info

About APhA DrugInfoLine

APhA DrugInfoLine (ISSN 2162-3015) is a weekly publication of, and is owned and copyrighted by the American Pharmacists Association, the national professional society of pharmacists. Materials in APhA DrugInfoLine do not neccessarily represent the policy, recommendations, or endorsement of APhA. The publisher, authors, editors, reviewers, and contributors have taken care to ensure that the information contained in APhA DrugInfoLine is accurate and current; however, they shall have no ability to any person or entity with regard to claims, losses, or damage caused or alleged to be caused, directly or indirectly by use of any information contained in the publication. All decisions about drug therapy must be based on independent judgement of the clinician.