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Alendronate Now Approved for Weekly Dosing


Based on the pharmacokinetics of alendronate (Fosamax—Merck) and the physiology of the bone-remodeling process, once-weekly administration of this bisphosphonate is just as effective as daily regimens. In fact, once-weekly dosing exposes the GI tract to less irritation than do daily doses, and patients generally prefer to take the 70 mg tablet once weekly.


Bone HG et al. Weekly administration of alendronate: rationale and plan for clinical assessment. Clin Ther. 2000;22:15–28.