Endocrinology

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New meta-analysis suggests menopausal hormone use increases breast cancer risk

KEY POINT

Women who initiated hormone replacement therapy (HRT) shortly after menopause had an increased risk of breast cancer compared with those who never used HRT, according to results of a large meta-analysis published in Lancet. The highest risk was observed in those who used estrogen plus progesterone and for more extended periods. 

SOURCES

Collaborative Group on Hormonal Factors in Breast Cancer. Type and timing of menopausal hormone therapy and breast cancer risk: Individual participant meta-analysis of the worldwide epidemiological evidence. Lancet. 2019;[Epub ahead of print].

Kotsopoulos J. Menopausal hormones: Definitive evidence for breast cancer. Lancet. 2019;[Epub ahead of print].

The North American Menopause Society. The 2017 hormone therapy position statement of The North American Menopause Society. Menopause. 2018;25(11):1362–87.