Endocrinology

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Regimens Can Differ for Mifepristone, Misoprostol in Medical Abortion

KEY POINT

Mifepristone (Mifeprex—Danco Laboratories) was approved in late September by FDA for use in a carefully described, physician-administered, three-visit plan. But according to a recently published article, the agent can be used in a somewhat simpler regimen, at lower doses, and for 1 week beyond the FDA-approved 49-day gestation period. Since this alternative regimen involves vaginal application of misoprostol (Cytotec—Searle), pharmacists may see orders for intravaginal use of oral misoprostol tablets or possibly be called on to compound vaginal suppositories.

SOURCES

Schaff EA et al. Vaginal misoprostol administered 1, 2, or 3 days after mifepristone for early medical abortion. JAMA. 2000;284:1943–53.

Schaff EA et al. Combined methotrexate and misoprostol for early induced abortion. Arch Fam Med. 1995;4:774–9.

Spitz IM et al. Early pregnancy termination with mifepristone and misoprostol in the United States. N Engl J Med. 2000;338:1241–7.