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Antibiotics, infections affect warfarin, but risk of harm is low

KEY POINT

Presence of an upper respiratory tract infection or use of antibiotics was associated with increased risk of elevated International Normalized Ratio (INR) in long-term warfarin users as compared with stable controls; however, clinically relevant bleeding and thromboembolic outcomes were similar across groups.  

SOURCES

Clark NP et al. Warfarin interactions with antibiotics in the ambulatory care setting. JAMA Intern Med. 2014;174:409–416.

Katz MH. Data for a common clinical dilemma [Editor’s note]. JAMA Intern Med. 2014;174:416.