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Bleeding risk with anticoagulants underestimated in clinical trials


A review of data from patients in a commercial health care claims database who were initiating either warfarin or dabigatran (Pradaxa—Boehringer Ingelheim) for atrial fibrillation (AF) found that the risks of thromboembolism was similar to those estimated by clinical trials; however, the risk of major bleeding with these agents was much higher in practice.