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Glyburide Study Opens Door to Oral Therapy of Gestational Diabetes


Because of early negative experiences with first-generation sulfonylureas, insulin has remained the mainstay of therapy in women with gestational diabetes mellitus. A recent study of glyburide—which does not cross the placental barrier as do older agents such as tolbutamide and chlorpropamide—reopens the discussion of whether this condition can be effectively and safely managed without the need for insulin injections. But questions remain.


Langer O et al. A comparison of glyburide and insulin in women with gestational diabetes mellitus. N Engl J Med. 2000;343:1134–8.

Greene MF. Oral hypoglycemic drugs for gestational diabetes [editorial]. N Engl J Med. 2000;343:1178–9.