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Short-term ART intensification does not reduce residual HIV in blood, gut, CNS

KEY POINT

Results from two clinical trials evaluating short-term antiretroviral therapy (ART) intensification—defined as the addition of an antiretroviral agent to an existing antiretroviral regimen that achieves an undetectable viral load—indicated that continued HIV replication is not the result of ongoing replication in the gut, blood, or central nervous system (CNS).