Focus on Lipids Care

Back to articles

Atherosclerosis and Endothelial Dysfunction: Lower Lipid Levels Can Help

KEY POINT

Regardless of the approach, lowering patients’ cholesterol levels improves endothelial function in affected arterial walls. In what could be a prelude to recommendations to reduce LDL-cholesterol levels beyond 100 mg/dL, recent studies demonstrate that aggressive lipid-lowering therapies stop or even reverse atherosclerotic processes.

SOURCES

Penny WF. Improvement of coronary artery endothelial dysfunction with lipid-lowering therapy: heterogeneity of segmental response and correlation with plasma-oxidized low density lipoprotein. J Am Coll Cardiol. 2001;37:766–74.

Diabetes Atherosclerosis Invervention Study Investigators. Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomised study. Lancet. 2001;357:905–10.

Smilde TJ et al. Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. Lancet. 2001;357:577–81.

Durrington PN. Rigorous detection and vigorous treatment of familial hypercholesterolaemia [editorial]. Lancet. 2001;357:574–5.