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Intensive Statin Therapy May Benefit Those with Stable Coronary Disease


Patients with stable coronary disease experienced a reduced risk of major cardiovascular events with high-dose statin therapy designed to lower LDL cholesterol to around 70 mg/dL, as compared with less intense therapy (target LDL-C < 100 mg/dL), which is currently recommended. Intensive statin therapy did not reduce the overall death rate but did reduce the number of cardiac events, according to findings presented last month at the American College of Cardiology’s annual scientific session 2005 in Orlando, simultaneously published online by the New England Journal of Medicine, and scheduled for printing in the April 7 issue of that journal.


LaRosa JC et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med. 2005:352.

Pitt B. Low-density lipoprotein cholesterol in patients with stable coronary heart disease—is it time to shift our goals [editorial]? N Engl J Med. 2005:352.

Grundy SM et al. NCEP report: implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Circulation. 2004;110:227–39. 

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