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Statins: Reductions in CRP Levels Important

KEY POINT

The effects that statins have on serum levels of C-reactive protein (CRP) may be more important in predicting clinical outcomes than the drugs’ reductions in LDL cholesterol concentrations.

SOURCES

Ridker PM et al. C-reactive protein levels and outcomes after statin therapy. N Engl J Med. 2005;352:20–8.

Nissen SE et al. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N Engl J Med. 2005;352:29–38.

Ehrenstein MR et al. Statins for atherosclerosis—as good as it gets [editorial]? N Engl J Med. 2005;352:73–5.