Gastroenterology

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Medications Linked to Esophageal Adenocarcinoma

KEY POINT

Long-term use of medications that relax the lower esophageal sphincter (LES) may be causing adenocarcinoma of the esophagus by permitting chronic reflux. Such drugs include nitroglycerins, aminophyllines, beta-receptor agonists, anticholinergic agents, and benzodiazepines.

SOURCES

Lagergren J et al. Association between medications that relax the lower esophageal sphincter and risk for esophageal adenocarcinoma. Ann Intern Med. 2000;133:165–75.

Eisen GM. The burning issue of chronic gastroesophageal reflux [editorial]. Ann Intern Med. 2000;133:227–9.