Nephrology

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High-dose I.V. N-acetylcysteine ineffective for the prevention of contrast-induced acute kidney injury

KEY POINT

Administration of high-dose I.V. N-acetylcysteine in patients with ST-segment elevation myocardial infarction (MI) undergoing primary angioplasty with moderate contrast volumes resulted in no clinical benefit compared with placebo with respect to contrast-induced nephropathy (CIN) or myocardial reperfusion injury.