Pharmacogenomics Corner

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New guideline updates simvastatin dosing recommendations based on gene polymorphism

KEY POINT

When SLCO1B1 genotyping is available in the clinical environment, information on the presence of a variant that increases simvastatin levels and muscle toxicity risk (rs4149056) should be used to individualize simvastatin doses and initiate routine creatinine kinase (CK) monitoring, according to a recent guideline.