Pharmacogenomics Corner

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Screening for extremely high lipoprotein (a) levels can improve cardiovascular risk prediction

KEY POINT

Incorporation of extremely elevated lipoprotein (a) levels and/or corresponding LPA gene variants into traditional measures of cardiovascular risk assessment improved myocardial infarction (MI) and coronary heart disease (CHD) risk prediction, especially in patients classified as “intermediate risk” by traditional measures.

SOURCES

Kamstrup PR et al. Extreme lipoprotein (a) levels and improved cardiovascular risk prediction. J Am Coll Cardiol. 2013;61:1146–56.