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Antipsychotic Agents & Schizophrenia: Differing Effects on a Progressive Disease


Reflecting the increasing recognition of schizophrenia as a progressive disease, two recently published studies indicate that brain morphology may be better preserved when affected patients are treated with atypical antipsychotic agents rather than older agents such as haloperidol.


Lieberman JA et al. Antipsychotic drug effects on brain morphology in first-episode psychosis. Arch Gen Psychiatry. 2005;62:361–70.

Massana G et al. Volume changes in gray matter in first-episode neuroleptic-naive schizophrenic patients treated with risperidone. J Clin Psychopharmacol. 2005;25:111–7.