Psychiatry

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First-trimester use of antipsychotics does not significantly increase risk of birth defects

KEY POINT

Exposure to first- or second-generation antipsychotics during the first trimester was not associated with an increased risk of congenital malformations or cardiac malformations, except for a small increased risk of congenital malformations with the use of risperidone, according to results of an observational cohort study published in JAMA Psychiatry.

SOURCES

Huybrechts KF, et al. Antipsychotic use in pregnancy and the risk for congenital malformations. JAMA Psychiatry. 2016;73(9):938–46.

Wisner KL, et al. Use of antipsychotics during pregnancy: Pregnant women get sick—sick women get pregnant. JAMA Psychiatry. 2016;73(9):901–3.