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Neonatal Withdrawal After Maternal SSRI Use During Pregnancy


Selective serotonin reuptake inhibitors (SSRIs) given during pregnancy have been associated with withdrawal symptoms—characterized by convulsions, irritability, abnormal crying, and tremor—in the neonate, according to a recently published article in the Lancet.


Sanz EJ et al. Selective serotonin reuptake inhibitors in pregnant women and neonatal withdrawal syndrome: a database analysis. Lancet. 2005;365:482–7.

Ruchkin V et al. SSRIs and the developing brain [comment]. Lancet. 2005;365:451–3.

Nordeng H et al. Neonatal withdrawal syndrome after in utero exposure to selective serotonin reuptake inhibitors. Acta Paediatr. 2001;90:288–91.