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Old Versus New: Which Agents Are Best for Chronic Schizophrenia?



Olanzapine (Zyprexa—Lilly) showed modest advantages compared with other antipsychotic medications, according to results of a major study funded by the National Institute of Mental Health, a part of NIH. This advantage in effectiveness was balanced by increased weight gain and other metabolic effects. Other second generation (atypical) antipsychotics demonstrated the same effectiveness as the first generation agent perphenazine.



Lieberman JA et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. 2005;353:1209–23.

Freedman R. The choice of antipsychotic drugs for schizophrenia [editorial]. N Engl J Med. 2005;353:1286–8.

Questions and answers about the NIMH Clinical Antipsychotic Trials of Intervention Effectiveness Study (CATIE). National Institutes of Mental Health, September 2005.