Psychiatry

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Risperidone Useful in Refractory Obsessive-Compulsive Disorder

KEY POINT

About one-half of patients whose obsessive-compulsive disorder (OCD) fails to respond to selective serotonin reuptake inhibitor (SSRI) therapy can be successfully treated with risperidone (Risperdal—Janssen). Contrary to previous research, refractory patients in this study responded regardless of whether they also had tic disorders or schizotypal personality disorder.

SOURCES

McDougle CJ et al. A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor–refractory obsessive-compulsive disorder. Arch Gen Psychiatry. 2000;57:794–801.