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Dexamethasone Not Needed for Lung Disease in Premature Neonates


High-dose dexamethasone has been used in premature neonates to reduce the risk of chronic lung disease but has been associated with unacceptable complications. Recently published data suggest that using moderate doses of dexamethasone instead does not prevent chronic lung disease and is still associated with serious side effects, including gastrointestinal perforation and decreased growth


Stark AR et al. Adverse effects of early dexamethasone treatment in extremely-low-birth-weight infants. N Engl J Med. 2001;344:95–101.