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Underappreciated Triad: Hypertension, Depression, & Sleep Apnea


The use of antihypertensive and antidepressant medications is associated with diagnosis of obstructive sleep apnea syndrome, especially in younger and middleaged people, according to an analysis of a managed care database containing records on more than 200,000 patients. The medications do not produce apnea; rather, hypertension and chronic fatigue or depression are manifestations of obstructive sleep apnea syndrome. These findings demonstrate that obstructive sleep apnea should be considered in patients who have hypertension and depression so that the underlying cause can be addressed.


Farney RJ et al. Simultaneous use of antidepressant and antihypertensive medications increases likelihood of diagnosis of obstructive sleep apnea syndrome. Chest. 2004;125:1279–85.

Sleep apnea. In: MedlinePlus Medical Encyclopedia.