Rheumatology

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Topical NSAIDs an Option for Rheumatic Diseases

KEY POINT

For many aches and pains associated with rheumatic diseases, NSAIDs reach levels in target tissues after topical administration similar to those achieved with oral administration. In several developed countries other than the U.S., topical NSAIDs are being used under the assumption that the route avoids the gastrointestinal (GI) toxicity of the agents. However, NSAIDs—even when injected—still inhibit protective enzymes in the GI lining.

SOURCES

Heyneman CA et al. Oral versus topical NSAIDs in rheumatic diseases: a comparison. Drugs. 2000;60:555–74.

Allen LV. Ketoprofen gel. US Pharm. 1993(Nov);18(11):98–100.